What is one sign associated with CNS depression?

Tiredness, or drowsiness, is a significant sign associated with central nervous system (CNS) depression. This state occurs when the functions of the CNS are slowed down, which can lead to an overall reduction in alertness and response to stimuli. CNS depressants, such as certain medications or substances, can cause this decreased level of consciousness, resulting in fatigue and lethargy.

In contrast, increased alertness would typically indicate a stimulated CNS rather than a depressed one. High blood pressure is often not directly associated with CNS depression; in some cases, it may actually lead to the opposite effect, which is CNS stimulation. Rapid speech can also reflect heightened CNS activity and is not characteristic of CNS depression, where slowed thought processing and communication would be more apparent. Thus, tiredness stands out as the most appropriate indicator of CNS depression.