Which of the following is NOT a sign of acute pulmonary edema?

Sudden weight gain is the option that does not typically present as a sign of acute pulmonary edema. In the context of acute pulmonary edema, the condition is characterized by the rapid accumulation of fluid in the lungs, which leads to symptoms such as cyanosis, frothy sputum, and tachycardia.

Cyanosis occurs due to insufficient oxygenation of the blood, presenting as a bluish tint in the skin and mucous membranes. Frothy sputum is often produced when fluid in the alveoli mixes with air, leading to a characteristic sputum appearance that can indicate severe pulmonary fluid overload. Tachycardia commonly occurs as the body attempts to compensate for decreased oxygen levels and increased load on the heart.

Sudden weight gain is generally not a sign of acute pulmonary edema; instead, it is often associated with fluid retention over a longer period rather than a rapid and acute condition. Therefore, it is not considered an immediate clinical manifestation of this specific respiratory emergency.